Cancer stem cell heterogeneity in hereditary breast cancer

Evaluation of Stem Cell Markers, CD44/CD24 in Breast Cancer Cell Lines

Background Cancer stem cells play crucial roles in resistance to therapeutic schemes and relapse of disease, so it is important to find targeted therapies that kill them selectively. Breast cancer is the most common cancer in females living in all part of the world including Iran and it has an important burden in public health with direct impact on patients’ families. Breast cancer in young ad...

Phenotypic Heterogeneity of Breast Cancer Stem Cells

Many types of tumors are organized in a hierarchy of heterogeneous cell populations, with only a small proportion of cancer stem cells (CSCs) capable of sustaining tumor formation and growth, giving rise to differentiated cells, which form the bulk of the tumor. Proof of the existence of CSC comes from clinical experience with germ-cell cancers, where the elimination of a subset of undifferenti...

Heterogeneity in breast cancer.

Breast cancer is a heterogeneous disease. There is a high degree of diversity between and within tumors as well as among cancer-bearing individuals, and all of these factors together determine the risk of disease progression and therapeutic resistance. Advances in technologies such as whole-genome sequencing and functional viability screens now allow us to analyze tumors at unprecedented depths...

Heterogeneity in Breast cancer

Breast cancer is malignant tumor occurred on breast epithelial tissue, although the mortality rate of breast cancer decreases, it remains one of the highest mortality rate diseases. Ignoring few exceptions, almost all tumors are derived from one single cancer cell. However, in clinical diagnosis, most human tumors demonstrate amazing heterogeneity in many morphological and physical characterist...

Hereditary Breast-Ovarian Cancer